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The 15th Annual
Peptide Therapeutics
Symposium

October 22 – 23, 2020

Sponsors

Program

The 15th Annual Peptide Therapeutics Symposium will be held in a virtual format from 8:00 am to 5:00 pm (PDT) on October 22nd and 23rd, 2020. An interactive poster session will be held each day. Registrants will have access to recorded presentations for 30 days following the close of the meeting.

Keynote 

Glenn King – The University of Queensland

Sarah Robertson – The University of Adelaide

Carlo Giovanni Traverso – Massachusetts Institute of Technology, Brigham and Women’s Hospital

Dehua Pei – The Ohio State University

Lecture

Michael Brownstein – Azevan Pharmaceuticals

Kathleen Caron – University of North Carolina at Chapel Hill

Daniel DeOliveira – Genocea Biosciences, Inc.

Ernest Giralt – IRB Barcelona

David E. Gloriam – University of Copenhagen

Kevin McDonnell – Bicycle Therapeutics

Daniel Obrecht – Polyphor AG

Kerry-Anne A. Perkins –Virtua Memorial Hospital

David Perrin – University of British Columbia

Weijun Shen  – Calibr at Scripps Research

Gregory Verdine – FogPharma

Kathryn A. Whitehead – Carnegie Mellon University

Lindon Young – Philadelphia College of Osteopathic Medicine

Final  Schedule:

Thursday, October 22, 2020

8:00 a.m. – 8:15 a.m.

Opening Remarks 

Phil Dawson,
Chairman of the Board, Peptide Therapeutics Foundation
Professor of Chemistry, Scripps Research
Dean of the Skaggs Graduate School of Chemical and Biological Sciences

8:15 a.m. – 9:45 a.m.

Session I

8:15 a.m. – 8:45 a.m.

From Farm to Pharmacy a Strawberry-Derived Solution to Oral Protein Delivery

Kathryn A. Whitehead, Carnegie Mellon University

8:45 a.m. – 9:15 a.m.

Building Novel Immune Cell Agonist Anti-Cancer Agents out of Bicycle Parts

Kevin McDonnell,
Bicycle Therapeutics

9:15 a.m. – 9:45 a.m.

Toward Universal Druggability

Gregory Verdine,
Harvard University and Harvard Medical School
Fog Pharmaceuticals and LifeMine Therapeutics

9:45 a.m. – 10:30 a.m.

Break

10:30 a.m. – 12:50 p.m.

Poster Break Out Sessions

10:30 a.m. – 10:50 a.m.

The U24 Protein of HHV-6A Induces the Expression of Alzheimer’s Disease Risk Factors of Microglial Cells

Giovanna Schiuma,
University of Ferrara, Department of Chemical and Pharmaceutical Chemistry, Italy

10:50 a.m. – 11:10 a.m.

Targeting SARS-CoV-2 Spike 1 Protein to Control Natural Killer Cells Activation via HLA-E/NKG2A Pathway

Sabrina Rizzo,
University of Ferrara, Department of Chemical and Pharmaceutical Sciences, Italy

11:10 a.m. – 11:30 a.m.

Reengineering the Antimicrobial Peptide from the Scorpion Venom of Opisthacanthus Madagascariensis into Highly Active Peptides with Low Toxicity

Cyntia Silva Oliveira,
Universidade Federal de São Paulo, Brazil

11:30 a.m. – 11:50 a.m.

Do Peptide Drugs Interact with Bile Salts in the Gastrointestinal Environment?

Tahnee Dening,
Department of Pharmaceutical Chemistry, University of Kansas

11:50 a.m. – 12:10 p.m.

Anionic Nanoparticles Enable Oral Peptide Delivery by Enhancing Intestinal Permeability

Nicholas Lamson,
Department of Chemical Engineering, Carnegie Mellon University

12:10 a.m. – 12:30 p.m.

Viral Insulin/IGF-1 like Peptides have Unique White Adipose Tissue Specific Characteristics in Mice

Martina Chrudinova,
Biology Department, Boston College

12:30 a.m. – 12:50 p.m.

Development of Pharmacoproteomics Assays for Dissecting the Molecular and Cellular Pathways Regulated by Anticoagulant Peptides in Platelets and Dendritic Cells

Cristina Clement,
Radiation Oncology Department, Weill Cornell Medicine

12:50 p.m. – 1:30 p.m.

Lunch Break

1:30 p.m. – 3:00 p.m.

Session II

1:30 p.m. – 2:00 p.m.

Adrenomedullin Functions at the Maternal-Fetal Interface

Kathleen Caron,
University of North Carolina at Chapel Hill

2:00 p.m. – 2:30 p.m.

Empowering Peptide Science through Easy 18F-labelling for PET Imaging and New Stapling Methods Inspired by Natural Product Toxins

David M. Perrin,
University of British Columbia

2:30 p.m. – 3:00 p.m.

A Peptide Engineering Platform for PEG-FA Stapled Long-acting Peptide Hormones

Weijun Shen,
Calibr at Scripps Research

3:00 p.m. – 3:30 p.m.

Break

3:30 p.m. – 5:00 p.m.

Plenary Lecture

3:30 p.m. – 4:15 p.m.

Novel Therapeutics for Inflammatory Disorders of Pregnancy-Opportunities and Challenges

Sarah Robertson,
The University of Adelaide

4:15 p.m. – 5:00 p.m.

Deadly Cures: A Spider-Venom Peptide for Treating Ischemic Injuries of the Heart and Brain

Glenn King,
The University of Queensland

Friday, October 23, 2020

8:00 a.m. – 8:15 a.m.

Welcoming Remarks

Soumitra Ghosh,
Director and President, Peptide Therapeutics Foundation
President, Doon Associates LLC

8:15 a.m. – 9:45 a.m.

Session III

8:15 a.m. – 8:45 a.m.

Peptides for Molecular Recognition and Brain Delivery

Ernest Giralt,
Institute for Research in Biomedicine (IRB Barcelona)

8:45 a.m. – 9:15 a.m.

Novel Pairings in the Human Peptide-Receptor Signaling System

David E. Gloriam,
University of Copenhagen

9:15 a.m. – 9:45 a.m.

Chimeric Macrocyclic Peptide Antibiotics Against WHO Priority 1 Gram-Negative Bacteria Targeting both Lipopolysaccharide and BamA

Daniel Obrecht,
Polyphor AG

9:45 a.m. – 10:30 a.m.

Break

10:30 a.m. – 12:00 p.m.

Plenary Lectures

10:30 a.m. – 11:15 a.m.

Cyclic Cell-Penetrating Peptides: Mechanism of Action and Applications

Dehua Pei,
The Ohio State University 

11:15 a.m. – 12:00 p.m

GI Device Development in a Few Movements

Giovanni Traverso,
Massachusetts Institute of Technology, Brigham and Women’s Hospital

12:00 p.m. – 1:00 p.m.

Lunch Break

1:00 p.m. – 2:30 p.m.

Session IV

1:00 p.m. – 1:30 p.m.

 

GEN-009: A Neoantigen Vaccine Based on Autologous Peptide Immune Responses

GEN-011: Transforming T cell Therapy for Solid Tumors

Daniel DeOliveira,
Genocea Biosciences, Inc.

1:30 p.m. – 2:00 p.m.

Vasopressin:  Old Dog.  New Tricks

Michael Brownstein,
Azevan Pharmaceuticals

2:00 p.m. – 2:30 p.m.

Dual Myristic Acid (Myr) and Trans Activator of Transcription (Tat) Conjugated Peptides: A Potential Platform Technology for Intracellular Cargo Delivery

Lindon Young,
Philadelphia College of Osteopathic Medicine

Kerry-Anne A. Perkins, Virtua Memorial Hospital

2:30 p.m. – 2:45 p.m.

Final Remarks

Adrienne Day,
Director and Treasurer, Peptide Therapeutics Foundation
Founder and Principal, Blue Gum Advisors

2:45 p.m. – 5:05 p.m.

Poster Break Out Sessions

2:45 p.m. – 3:05 p.m.

Protein Kinase C-Epsilon Inhibitor Conjugated with Myristic Acid and Trans-Activator of Transcription Elicits Superior Cargo Delivery and Cardioprotective Effects in Rat Myocardial Ischemia-Reperfusion Injury

Tameka Dean,
Philadelphia College of Osteopathic Medicine

3:05  p.m. – 3:25 p.m.

Protein Kinase C Beta II Peptide Inhibitor Conjugated to a Novel Myristic Acid-Trans- Activator – Tandem Rapidly Attenuates Superoxide Release in Isolated Rat Polymorphonuclear Leukocytes through Superior Intracellular Delivery of Cargo

Sunit Singh,
Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine

3:25  p.m. – 3:45 p.m.

Overcoming the Blood-Brain-Barrier by a Linear 7-Mer Peptide, IF7, with Binding Specificity to Annexin A1 in Brain Tumors

Michiko Fukuda,
Cancer Center, Sanford-Burnham-Prebys Medical Discovery Institute

3:45  p.m. – 4:05 p.m.

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents

David Salehi,
Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy

4:05 p.m. – 4:25 p.m.

Design and Evaluation of Cyclic and Linear Amphiphilic Peptides Against Multidrug-Resistant Bacterial Pathogens

Keykavous Parang,
Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy

4:25 p.m. – 4:45 p.m.

Characterisation of a Lunasin-Derived Anti-Inflammatory Peptide

Reynold Philip,
Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD Australia

4:45 p.m. – 5:05 p.m.

Potent Anticolorectal Cancer Activity of Analog Peptides Derived from Parasporin-2Aa1

Jenniffer Cruz,
Universidad de Santander, Bucaramanga, Colombia

News
Symposium

Peptide Therapeutic Foundation announces the recipients of the Ferring Research Institute Innovation Grants Program for 2019:
Katherine Burns – University of Cincinnati, College of Medicine
Charbonney Emmanuel – CHUM, University of Montreal
James Checco – University of Nebraska-Lincoln
Jennifer Condon – Wayne State University
Chen Huei Leo – Singapore University of Technology & Design
Carlos Penha-Goncalves – Instituto Gulbenkian de Ciencia
Giorgio Ivan Russo – University of Catania
Xiaoqin Ye – University of Georgia

Meet the 2018 Recipients:
Fiona Cousins – Hudson Institute of Medical Research, Monash University
Laurent Derré – University Hospital of Lausanne (CHUV)
Marta Dueñas – Fundación para la Investigación Hospital 12 de Octubre
Tracey Edgell – Hudson Institute of Medical Research, Monash University
Pradipta Ghosh – University of California, San Diego
Emmet Hirsch – NorthShore University HealthSystem
Sarah Marshall – Monash University
Harmeet Malhi – Mayo Clinic
Hiroshi Miyamoto – University of Rochester

October 22-23, 2020

The 15th Annual Peptide
Therapeutics Sympsium

The Salk Institute
La Jolla, California

Sponsors